Willow offers oral-dissolving GLP-1 tablets as a needle-free alternative to injectable treatment. There are two tablet options: Semaglutide* and Tirzepatide*. Both dissolve under your tongue, no injections, no cold storage, no syringes required.
*These tablets are compounded by licensed U.S. pharmacy partners. There is no FDA-approved oral-dissolving formulation of semaglutide or tirzepatide; licensed pharmacies may compound these formulations under applicable pharmacy regulations. Willow is not the compounder or manufacturer.
Your tablet options
Semaglutide Tablet* - $299-$399/month
An oral dissolving tablet containing semaglutide. Taken once daily. No needles, no fridge, easy to travel with.
Tirzepatide Tablet* - $399–$459/month
An oral dissolving tablet containing tirzepatide. Taken once daily, the same way as the semaglutide tablet. Your doctor determines the appropriate starting dose and plan.
Semaglutide/Tirzepatide Combination Tablet* - $399–$459/month
Ask your doctor for more information.
How oral dissolving tablets work
These tablets dissolve under your tongue and are absorbed through the lining of the mouth rather than swallowed. They work on the same GLP-1 pathway as injectable treatment, helping regulate appetite, support fullness, and slow gastric emptying. The key difference from injectables is how and when you take them: once daily by mouth versus once weekly by injection.
How to take your tablet: step by step
These instructions apply to both the Semaglutide and Tirzepatide tablets.
Start with a clean mouth. Avoid eating or drinking immediately before taking your dose. If you’ve recently eaten, swish a small amount of water around your mouth and spit it out first.
Take one tablet in the morning. Morning dosing is recommended. Taking it early in the day can help with appetite control during typical eating hours. Take only your prescribed dose.
Place the tablet under your tongue. Gently lift your tongue and place one tablet underneath. Try not to talk while it dissolves.
Let it dissolve completely. Do not chew or swallow the tablet. Allow it to fully dissolve until you can no longer taste it; this usually takes a few minutes.
Wait 30 minutes before eating or drinking. Once the tablet has fully dissolved, wait at least 30 minutes before eating, drinking anything other than water, or taking other oral medications, unless your doctor has directed otherwise.
Taking your tablet at the same time each morning helps keep steady medication levels in your body. Set a daily reminder if that helps. Missing an occasional dose is common and usually not harmful, but a consistent routine gives the medication the best chance to work effectively. If you take other oral medications, ask your doctor about timing to avoid interference with absorption.
Storing your tablets
Store at room temperature.
Keep tablets in their original container.
Protect from heat, moisture, and direct sunlight; avoid storing in bathrooms.
No refrigeration required; easy to pack and travel with
Potential side effects
GLP-1 medications can cause side effects. This includes:
Common: nausea, vomiting, diarrhea, constipation. These are most likely in the first few weeks and often improve as your body adjusts.
Less common but serious: pancreatitis, gallbladder disease, gastroparesis, worsening of diabetic eye disease, thyroid tumors. Seek emergency care for severe abdominal pain.
Frequently Asked Questions
What if I miss a dose?
If you miss a dose, do not double up. Take your next tablet at your usual scheduled time. If you miss several doses or feel unsure, contact your Willow doctor through the patient portal.
What time of day should I take my tablet?
Morning is recommended. Taking it early in the day may provide the most benefit for appetite control during typical eating hours.
Can I swallow the tablet instead?
No. These tablets are designed to dissolve under the tongue. Swallowing them may reduce effectiveness.
What is the difference between tablets and injectables?
Both oral tablets and injectables work on the same GLP-1 pathway to help control appetite and hunger. The difference between these two is not how they work, but how they are taken. Tablets are taken daily and dissolve under the tongue, while injectables are taken weekly using a needle.
Questions about your tablets? Message your Willow doctor through the patient portal, or reach the Care Team at [email protected]. You’re not expected to get everything right on day one. We’re here to help.
Compounded medications are not FDA-approved for safety, quality, or effectiveness and are not brand-equivalent. A valid prescription is required and availability varies by state. Side effects may include nausea, vomiting, diarrhea, constipation, abdominal pain, decreased appetite, and indigestion. Willow is not the compounder or manufacturer. Results may vary. Product images are for illustration only. Talk to your provider to determine if treatment is appropriate for you.